In 1956 Professor M. Mordarski in his medical search for new antibiotics investigated the bitter white juice of the small ginger mushroom Lactarius rufus. He discovered its antibiotic properties.
Fourteen years later Polish organic chemists isolated a lactone lactarorufin A and other lactones from Lactarius rufus and the olivaceous mushroom Lactarius necator. Sesquiterpene lactones were also isolated from many other Lactarius and Russula antibiotic fungi. They had sharp, bitter taste.
For the last thirty years Polish, Italian and Swedish researchers have been investigating Lactarius and Russula sesquiterpenes and have established their structure. Most of them are lactones with lactarane or marasmane skeleton, some have furan ring in the molecule. Some have antibiotic properties. They bring optimal natural health.
They investigated also their chemical reactions.
Some Lactarius sesquiterpenes, for example lactarorufin A and furandiol have strong repellent, antifeedant activity against certain pests. These natural products have deterrent properties, are deterrents. They are natural antibiotics, too. These properties are scientifically proven.
Natural antibiotics new developments deserve to be further continued. Sesquiterpenes from Russula or Lactarius antibiotic fungi should be used in medical area by a pharmaceutical company. They should be used in alternative medicines. These natural compounds will be mild, selective antibiotics.
Lactarorufin A, one of natural antibiotics, sesquiterpene lactone from antibiotic fungi Lactarius necator and Lactarius rufus
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Natural antibiotics new developments, sesquiterpenoids or other isoprenoids relevant links, with my rating (* * * *)
Antibiotic activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii
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Antibiotic activity of sesquiterpene lactones of the helenanolid type from Arnica Flower (Arnica montana or A. chamissonis subsp.) * * * * *
Forest Herbs Research Ltd - The Science of Polygodial. Polygodial - a hot tasting sesquiterpene dialdehyde in the plants Polygonum hydropiper and Pseudowintera colorata; Antifungal and antibiotic activity against Candida albicans
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Sesquiterpenes isolated from Lactarius mushrooms, which possess lactarane isolactarane and marasmane skeletons, some of the compounds exhibit antifeedant, antibacterial and antiviral properties; Info on recent Polish investigations
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