The broad Ohio River forms a natural boundary.
Down through history it has served to separate many rival cultures.

It is the Spring of 1774:

The Ohio River separates the rapidly growing colony of Virginia from the Indian Nations, then called the Great Northwest Indian Territory. Logan lives as a man of peace, greeting the newly arriving trappers and fur traders from the Virginia Colony as friends. Until his family falls victim to the influx of settlers and are murdered. His vengence was severe and led to the Battle of Point Pleasants, often thought to be the first battle of the Revolutionary War.