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Amitabha Chakrabarti
Research Instructor, Department of Psychiatry
Vanderbilt University Medical Center
1161 21st Ave S, Nashville, TN 37232

Laboratory:Medical Center North
Room(s): A2112A
Phone:(615)-343-9879
Fax:(615)-343-8639
E-mail:amitabha.chakrabarti@vanderbilt.edu
          amitabha.chakrabarti@mcmail.vanderbilt.edu

Data obtained so far from different research studies, when considered alone or in conjunction with others do not elucidate the complete interplay of different factors towards explaining the underlying principles of affective disorder and thereby fail to suggest any assertive marker of major depression. The best way of addressing the problem is to have a panoramic view of as many as possible of all the relevant gene expressions at different points of manifestation of the disorder and its theraputic reversal to compare those finding for differential expressions. This can be done using appropriate animal model that can mimic major depression in humans. Chronic Mild Stress Model as suggested by Willner and Papp can be successfully used for this purpose. Brain tissues collected from animals used in this model will be analyzed in our laboratory for differential expression of different known and novel genes using cDNA Expression Array and Differential Display techniques.

As a post doctoral fellow I have studied the molecular neuropharmacology of the effect of cannabinoid receptor and its endogenous ligand anandamide. In the last couple of years I have developed an interest in the molecular psychopharmacology of affective disorder and finally this has become my sole commitment. It is expected that the studies of underlying principles of depression and its treatment will have a new inertia in the coming years of research in our laboratory.

Selected List of My Publications

  1. Chirwa SS, Chakrabarti A, Motley E, and Onaivi ES (1998) Effects of chronic methamphetamine in hippocampus. Communicated.
  2. Onaivi ES, Ali SF and Chakrabarti A (1998) In vivo ibogaine blockade and in vitro PKC action of cocaine. Ann N Y Acad Sci 844, 227-244.
  3. Chakrabarti A, Ekuta JE, and Onaivi ES (1998) Neurobehavioral effects of anandamide and cannabinoid receptor gene expression in mice. Brain Research Bulletin 45(1), 67-74.
  4. Onaivi ES, Bishop-Robinson C, Chakrabarti A, Motley ED and Chirwa SS (1996) Neurobiological actions of cocaine in the hippocampus. Ann N Y Acad Sci 801, 76-86.
  5. Onaivi ES, Chakrabarti A and Chaudhuri G (1996) Cannabinoid receptor genes. Prog Neurobiol 48, 275-305.
  6. Stubbs L, Chittenden L, Chakrabarti A and Onaivi ES (1996) The mouse cannabinoid receptor gene is located in proximal chromosome 4. Mammalian Genome 7,165-166.
  7. Onaivi ES, Chakrabarti A, Gwebu ET and Chaudhuri G (1995) Neurobehavioral specificity of cannabinoid receptor gene expression in mice. Behav Brain Res 72, 115-125.
  8. Chakrabarti A, Onaivi ES and Chaudhuri G (1995) Structural characterization of cannabinoid receptor genes.NIDA Research Monograph 153, 301.
  9. Chakrabarti A, Onaivi ES and Chaudhuri G (1995) Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein. DNA Sequence 5, 385-388.
  10. Chakrabarti A, Sitaric S and Ohi S (1992) A procedure for large-scale plasmid isolation without using ultracentrifugation. Biotechnology and Applied Biochemistry 16, 211-215.
  11. Sarkar AK, Chakrabarti A, Saha UK and Sengupta D (1989) Effects of aspirin and paracetamol on ATPases of human fetal brain: An in vitro study. Ind. J. Exp. BioL 27, 802-804.
  12. Chakrabarti A, Sarkar A, De S and Sengupta D (1987) Possibility of impairement of human fetal brain development due to sodium valproate intake during pregnancy: In vitro effect on fetal brain cholinesterase activity. Applied Nutrition 12, 37-40.
  13. Chakrabarti A, Sarkar A, De S and Sengupta D (1986) In vitro effect of haloperidol (haldol) on cholinestrase activity of fetal brain. IRCS Med. Sci 14, 461-466.
  14. Chakrabarti A, De S and Sengupta D (1984) Effect of sodium valproate on magnesium and sodium + potassium adenosine triphosphatases of human fetal brain. Ind. J. Exp. Biol 22, 343-344.

 

 


This webpage has been created By Amitabha Chakrabarti
This website is maintained by Amitabha Chakrabarti
For comments please email me at amitabha.chakrabarti@vanderbilt.edu